Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase
Author/Authors :
Pamela Brown، نويسنده , , Drake S. Eggleston، نويسنده , , R. Curtis Haltiwanger، نويسنده , , Richard L. Jarvest، نويسنده , , Lucy Mensah، نويسنده , , Peter J. OʹHanlon، نويسنده , , Andrew J. Pope، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
4
From page :
711
To page :
714
Abstract :
Novel inhibitors of bacterial tyrosyl tRNA synthetase have been synthesised in which the cyclic hydroxylamine moiety of SB-219383 is replaced by C-pyranosyl derivatives. Potent and selective inhibition of bacterial tyrosyl tRNA synthetase was obtained.
