Author/Authors :
Richard L. Jarvest، نويسنده , , John M. Berge، نويسنده , , Pamela Brown، نويسنده , , Dieter W. Hamprecht، نويسنده , , David J. McNair، نويسنده , , Lucy Mensah، نويسنده , , Peter J. OʹHanlon، نويسنده , , Andrew J. Pope، نويسنده ,
Abstract :
Novel pyranosyl analogues of SB-219383 have been synthesised to elucidate the structure–activity relationships around the pyran ring. Analogues with highly potent stereoselective and bacterioselective inhibition of bacterial tyrosyl tRNA synthetase have been identified. A major reduction in the overall polarity of the molecule can be tolerated without loss of the nanomolar level of inhibition.
