Author/Authors :
Hélène Juteau، نويسنده , , Yves Gareau، نويسنده , , Marc Labelle، نويسنده , , Sonia Lamontagne، نويسنده , , Nathalie Tremblay، نويسنده , , Marie-Claude Carrière، نويسنده , , Nicole Sawyer، نويسنده , , Danielle Denis، نويسنده , , Kathleen M. Metters، نويسنده ,
Abstract :
Potent and selective EP3 receptor ligands were found by making a library using solid-support chemistry. These compounds can be obtained by a Suzuki coupling reaction of a solid-supported benzyl bromide using various boronic acids. The yields obtained for this reaction were in the range of 24–95% of arylmethyl cinnamic acid 1 after cleavage from the Wang resin.
