Title of article
2,4-thiazolidinediones as potent and selective human β3 agonists
Author/Authors
Baihua Hu، نويسنده , , John Ellingboe، نويسنده , , Iwan Gunawan، نويسنده , , Stella Han، نويسنده , , Elwood Largis، نويسنده , , Zenan Li، نويسنده , , Michael Malamas، نويسنده , , Ruth Mulvey، نويسنده , , Alexander Oliphant، نويسنده , , Fuk-Wah Sum، نويسنده , , Jeff Tillett، نويسنده , , Victoria Wong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
757
To page
760
Abstract
Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC50=0.01 μM, IA=1.19) and selective (more than 110-fold over β1 and β2 agonist activity) β3 agonist. This compound has also been proven to be active and selective in an in vivo mode.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791268
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