Author/Authors :
Junko Ohkanda، نويسنده , , Jeffrey W. Lockman، نويسنده , , Kohei Yokoyama، نويسنده , , Michael H. Gelb، نويسنده , , Simon L. Croft، نويسنده , , Howard Kendrick، نويسنده , , Maria Isabel Harrell، نويسنده , , Jean E. Feagin، نويسنده , , Michelle A. Blaskovich، نويسنده , , Said M. Sebti، نويسنده , , Andrew D. Hamilton، نويسنده ,
Abstract :
Malaria continues to represent a very serious health problem in the tropics. The current methods of clinical treatment are showing deficiencies due to the increased incidence of resistance in the parasite. In the present paper we report the design, synthesis, and evaluation of potential antimalarial agents against a novel target, protein farnesyltransferase. We show that the most potent compounds are active against Plasmodium falciparum in vitro at submicromolar concentrations.
