Title of article
Discovery of zoniporide: A potent and selective sodium–hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility
Author/Authors
Angel Guzman-Perez، نويسنده , , Ronald T. Wester، نويسنده , , Mary C. Allen، نويسنده , , Janice A. Brown، نويسنده , , Allan R. Buchholz، نويسنده , , Ewell R. Cook، نويسنده , , Wesley W. Day، نويسنده , , Ernest S. Hamanaka، نويسنده , , Scott P. Kennedy، نويسنده , , Delvin R. Knight، نويسنده , , Paul J. Kowalczyk، نويسنده , , Ravi B. Marala، نويسنده , , Christian J. Mularski، نويسنده , , William A. Novomisle، نويسنده , , Roger B. Ruggeri، نويسنده , , W. Ross Tracey، نويسنده , , Roger J. Hill، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
803
To page
807
Abstract
Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous administration. The discovery, synthesis, activities, and rat and dog pharmacokinetics of this compound are presented. The potency and selectivity of zoniporide may be due to the conformation that the molecule adopts due to the presence of a cyclopropyl and a 5-quinolinyl substituent on the central pyrazole ring of the molecule.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791279
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