Title of article
Novel inhibitors of the enzyme estrone sulfatase (ES)
Author/Authors
A. S. M. Sabbir Ahmed، نويسنده , , Karen James، نويسنده , , Caroline P. Owen، نويسنده , , Chirag K. Patel، نويسنده , , Mijal Patel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
841
To page
844
Abstract
We report the initial results of our study into a series of simple 4-sulfamated phenyl alkyl ketones as potential inhibitors of the enzyme estrone sulfatase. The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker activity than EMATE. Furthermore, the compounds are observed to be irreversible inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791288
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