Author/Authors :
Seigo Ishibuchi، نويسنده , , Hiroshi Morimoto، نويسنده , , Takanori Oe، نويسنده , , Tsuguo Ikebe، نويسنده , , Hiroyoshi Inoue، نويسنده , , Atsushi Fukunari، نويسنده , , Miho Kamezawa، نويسنده , , Ichimaro Yamada، نويسنده , , Yoichi Naka، نويسنده ,
Abstract :
A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.
