Title of article
Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists
Author/Authors
Yuguang Wang، نويسنده , , Samuel Chackalamannil، نويسنده , , Wei Chang، نويسنده , , William Greenlee، نويسنده , , Vilma Ruperto، نويسنده , , Ruth A. Duffy، نويسنده , , Robert McQuade، نويسنده , , Jean E. Lachowicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
891
To page
894
Abstract
Novel, selective M2 muscarinic antagonists, which replace the metabolically labile styrenyl moiety of the prototypical M2 antagonist 1 with an ether linkage, were synthesized. A detailed SAR study in this class of compounds has yielded highly active compounds that showed M2Ki values of <1.0 nM and >100-fold selectivity against M1, M3, and M5 receptors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791300
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