Title of article
Different antagonist binding properties of human and rat histamine H3 receptors
Author/Authors
Holger Stark، نويسنده , , Wolfgang Sippl، نويسنده , , Xavier Ligneau، نويسنده , , Jean-Michel Arrang، نويسنده , , C. Robin Ganellin، نويسنده , , Jean Charles Schwartz، نويسنده , , Walter Schunack، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
951
To page
954
Abstract
Different histamine H3-receptor antagonists have been tested in displacement studies at human and rat H3 receptors in stably transfected cells. Based on an actual rhodopsin structure, models for receptor–antagonist interaction were developed for receptors of both species. Similarities and discrepancies in binding profiles can be explained, but not quantified by hydrophilic interactions with Asp114 and an important lipophilic binding pocket modified by two nearby amino acids.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791313
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