Title of article
Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists
Author/Authors
James T. Link، نويسنده , , Bryan Sorensen، نويسنده , , Gang Liu، نويسنده , , Zhonghua Pei، نويسنده , , Edward B. Reilly، نويسنده , , Sandra Leitza، نويسنده , , Greg Okasinski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
973
To page
976
Abstract
Diarylsulfide cyclopropylamides were synthesized and evaluated as LFA-1/ICAM-1 interaction antagonists. A substituent pattern was identified which maximized potency and minimized protein binding as exemplified by antagonist 30 (IC50=5 nM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791318
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