Title of article :
Stereocontrolled synthesis of LNA Dinucleoside phosphorothioate by the oxathiaphospholane approach
Author/Authors :
Boles aw Karwowski، نويسنده , , Andrzej Okruszek، نويسنده , , Jesper Wengel، نويسنده , , Wojciech J. Stec and Linda Jen-Jacobson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
The application of the oxathiaphospholane approach for the stereocontrolled synthesis of LNA dinucleoside phosphorothioate is described. The reaction of ring opening condensation proceeds in CH3CN solution in high yield and with over 96% stereoselectivity. One of diastereomers of LNA dinucleoside phosphorothioate (presumably RP) was found to be readily digested by svPDE.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
