Title of article
Study of aminoglycoside–nucleic acid interactions by an HPLC method
Author/Authors
Violetta Constantinou-Kokotou، نويسنده , , George Karikas، نويسنده , , George Kokotos، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1015
To page
1018
Abstract
The interactions of a number of aminoglycoside antibiotics with tRNA and DNA were studied by an HPLC method, based on tRNA and DNA peak size exclusion. Among the compounds studied (deoxystreptamine, neamine, neomycin B, kanamycin A, gentamicin A, netilmicin, streptomycin, and the synthetic neamine analogue BKN3), neomycin B and the synthetic analogue of neamine were proved to be the most potent binders.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791327
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