Author/Authors :
A. Clemente، نويسنده , , A. Domingos، نويسنده , , A. P. Grancho، نويسنده , , J. Iley، نويسنده , , Jose R. Moreira، نويسنده , , J. Neres، نويسنده , , N. Palma، نويسنده , , A. B. Santana، نويسنده , , E. Valente، نويسنده ,
Abstract :
A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the β-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme.
