Author/Authors :
Peter Lin، نويسنده , , Dominick Marino، نويسنده , , Jane-Ling Lo، نويسنده , , Yi Tien Yang، نويسنده , , Kang Cheng، نويسنده , , Roy G. Smith، نويسنده , , Michael H. Fisher، نويسنده , , Matthew J. Wyvratt Jr.، نويسنده , , Mark T. Goulet، نويسنده ,
Abstract :
A series of 2-(3,5-dimethylphenyl)tryptamine derivatives was prepared and evaluated on a rat gonadotropin releasing hormone receptor assay. Some para-substituents on the 4-phenylbutyl side chain attached to the tryptamine nitrogen led to compounds with potent GnRH receptor binding. The study has helped define structural requirements for GnRH receptor binding for the 2-aryltryptamine GnRH antagonists.
