Author/Authors :
David L. Selwood، نويسنده , , David G. Brummell، نويسنده , , Robert C. Glen، نويسنده , , Maria C. Goggin، نويسنده , , Karen Reynolds، نويسنده , , Mark A. Tatlock، نويسنده , , Grant Wishart، نويسنده ,
Abstract :
A lipophilicity constrained library of 5-carboxamido 1-benzyl-3-(3-dimethylaminopropyloxy)-1H-pyrazoles was prepared by solution-phase parallel synthesis with removal of acidic by-products using the strongly basic MP-carbonate resin. Compounds show both activation of soluble guanylate cyclase and inhibition of platelet aggregation. Compound 12 also shows 22% oral bioavailability in rats.
