Author/Authors :
Lawrence J. Wilson، نويسنده , , Timothy W. Morris، نويسنده , , Qimin Wu، نويسنده , , Paul J. Renick، نويسنده , , Christian N. Parker، نويسنده , , Michael C. Davis، نويسنده , , Helana D. McKeever، نويسنده , , Paul M. Hershberger، نويسنده , , A. Greg Switzer، نويسنده , , Gary Shrum، نويسنده , , Shyam Sunder، نويسنده , , David R. Jones، نويسنده , , Shari S. Soper، نويسنده , , Roy L. M. Dobson، نويسنده , , Thomas Burt، نويسنده , , Kenneth L. Morand، نويسنده , , Mark Stella، نويسنده ,
Abstract :
An effort to identify novel inhibitors of peptidoglycan synthesis with antibacterial activity resulted in the discovery of a series of biaryl urea-based antibacterial agents through isolation of a by-product from a mixture-based combinatorial library of semi-carbazones and subsequent parallel synthesis efforts. The compounds were shown to possess broad spectrum antibacterial activity against gram-positive drug resistant pathogens, and showed apparent specificity for disruption of the bacterial cell wall biosynthesis pathway.
