Author/Authors :
Pascale Schumann، نويسنده , , Valérie Collot، نويسنده , , Yannick Hommet، نويسنده , , Willy Gsell، نويسنده , , François Dauphin، نويسنده , , Jana Sopkova، نويسنده , , Eric T. MacKenzie، نويسنده , , Dominique Duval، نويسنده , , Michel Boulouard، نويسنده , , Sylvain Rault، نويسنده ,
Abstract :
The synthesis and pharmacological evaluation of methoxyindazoles as new inhibitors of neuronal nitric oxide synthase are presented. The 7-methoxyindazole, although less potent than 7-NI, is the most active compound of the series in an in vitro enzymatic assay of neuronal nitric oxide synthase activity. This result shows that the nitro-substitution is not indispensable to the biological activity of the indazole ring. 7-Methoxyindazole possesses in vivo NOS inhibitory as well and related antinociceptive properties.
