Title of article
Synthesis and Evaluation of Efavirenz (SustivaTM) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain
Author/Authors
Anthony J. Cocuzza، نويسنده , , Dennis R. Chidester، نويسنده , , Beverly C. Cordova، نويسنده , , Susan Jeffrey، نويسنده , , Rodney L. Parsons، نويسنده , , Lee T. Bacheler، نويسنده , , Susan Erickson-Viitanen، نويسنده , , George L. Trainor، نويسنده , , Soo S. Ko، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
1177
To page
1179
Abstract
Two series of efavirenz analogues have been developed: one in which the cyclopropane ring has been replaced by small heterocycles and another in which the entire acetylenic side chain has been replaced by alkyloxy groups. Several members of both series show equivalent potency to efavirenz against both wild-type virus and the key K103N mutant.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791366
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