Author/Authors :
Ralph P. Robinson، نويسنده , , Ellen R. Laird، نويسنده , , Kathleen M. Donahue، نويسنده , , Lori L. Lopresti-Morrow، نويسنده , , Peter G. Mitchell، نويسنده , , Matthew R. Reese، نويسنده , , Lisa M. Reeves، نويسنده , , Amber I. Rouch، نويسنده , , Ethan J. Stam، نويسنده , , Sue A. Yocum، نويسنده ,
Abstract :
A novel series of imidazolidinone-based matrix metalloproteinase (MMP) inhibitors was discovered by structural modification of pyrrolidinone 1a. Potent inhibition of MMP-13 was exhibited by the analogues having 4-(4-fluorophenoxy)phenyl (4a, IC50=3 nM) and 4-(naphth-2-yloxy)phenyl (4h, IC50=4 nM) as P1′ groups.
