Author/Authors :
Kouichi Kikuchi، نويسنده , , Katsuya Tagami، نويسنده , , Shigeki Hibi، نويسنده , , Hiroyuki Yoshimura، نويسنده , , Naoki Tokuhara، نويسنده , , Kenji Tai، نويسنده , , Takayuki Hida، نويسنده , , Toshihiko Yamauchi، نويسنده , , Mitsuo Nagai، نويسنده ,
Abstract :
In the course of studies on novel retinoids, we have designed and synthesized a series of quinoline derivatives. One of them, 4-[5-[8-(1-methylethyl)-4-phenyl-2-quinolinyl]-1H-2-pyrrolyl]benzoic acid (12f) shows potent RARα-selective antagonistic activity.
