Title of article
Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists
Author/Authors
Kouichi Kikuchi، نويسنده , , Katsuya Tagami، نويسنده , , Shigeki Hibi، نويسنده , , Hiroyuki Yoshimura، نويسنده , , Naoki Tokuhara، نويسنده , , Kenji Tai، نويسنده , , Takayuki Hida، نويسنده , , Toshihiko Yamauchi، نويسنده , , Mitsuo Nagai، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1215
To page
1218
Abstract
In the course of studies on novel retinoids, we have designed and synthesized a series of quinoline derivatives. One of them, 4-[5-[8-(1-methylethyl)-4-phenyl-2-quinolinyl]-1H-2-pyrrolyl]benzoic acid (12f) shows potent RARα-selective antagonistic activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791375
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