• Title of article

    Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands

  • Author/Authors

    Thomas M. B?hme، نويسنده , , Christine Keim، نويسنده , , Gerd Dannhardt، نويسنده , , Ernst Mutschler PhD MD، نويسنده , , Günter Lambrecht، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2001
  • Pages
    3
  • From page
    1241
  • To page
    1243
  • Abstract
    In our search for M2-selective muscarinic receptor antagonists, we synthesized 1,3-disubstituted indenes. The effects of different basic moieties with regard to binding and selectivity towards the five distinct muscarinic receptor subtypes were investigated. The results show that the quinuclidine series afforded the most promising compounds in terms of both receptor affinity and M2-subtype selectivity.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2001
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    791381

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791381