Title of article
The synthesis of amino-acid functionalized β-Carbolines as topoisomerase II inhibitors
Author/Authors
Amy Morin Deveau، نويسنده , , Marc A. Labroli، نويسنده , , Christine M. Dieckhaus، نويسنده , , Mary T. Barthen، نويسنده , , Kirsten S. Smith، نويسنده , , Timothy L. Macdonald، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
1251
To page
1255
Abstract
The synthesis and biological activity of amino acid functionalized β-carboline derivatives, which are structurally related to azatoxin and the tryprostatins, are reported. These compounds were assayed for their growth inhibition properties in H520 and PC3 cell lines and were examined for their abilities to inhibit topoisomerase II-mediated DNA relaxation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791384
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