Title of article
Synthesis and Antifungal Activities of Novel 1,3-β- -Glucan Synthase Inhibitors. Part 2
Author/Authors
Kazunao Masubuchi، نويسنده , , Takehiro Okada، نويسنده , , Masami Kohchi، نويسنده , , Takeshi Murata، نويسنده , , Masao Tsukazaki، نويسنده , , Osamu Kondoh، نويسنده , , Toshikazu Yamazaki، نويسنده , , Yasuko Satoh، نويسنده , , Yoshinori Ono، نويسنده , , Toshiyuki Tsukaguchi، نويسنده , , Kazuko Kobayashi، نويسنده , , Naomi Ono، نويسنده , , Tomoaki Inoue، نويسنده , , Ikuo Horii، نويسنده , , Nobuo Shimma، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1273
To page
1276
Abstract
Highly potent 1,3-β- -glucan synthase inhibitors, 7b, 10a, 10b and 12, have been identified by the chemical modification of the ornithine residue of a fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. These compounds showed stronger antifungal activity against systemic candidiasis as well as pulmonary aspergillosis in mice, and less hepatotoxicity as compared with 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791389
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