Author/Authors :
Yiyun Huang، نويسنده , , Lawrence S. Kegeles، نويسنده , , Sung-A Bae، نويسنده , , Dah-Ren Hwang، نويسنده , , Bryan L. Roth، نويسنده , , Jason E. Savage، نويسنده , , Marc Laruelle، نويسنده ,
Abstract :
A series of dopamine D4 antagonists was synthesized and evaluated as potential candidates for development as positron emission tomography (PET) radioligands. All new compounds display high affinity and selectivity for the D4 receptors and compounds 5b, 5d, and 5e were identified as candidates for radioligand development.
