Title of article
MEK (MAPKK) inhibitors. Part 2: structure–activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines
Author/Authors
Nan Zhang، نويسنده , , Biqi Wu، نويسنده , , Nancy Eudy، نويسنده , , Yanong Wang، نويسنده , , Fei Ye، نويسنده , , Dennis Powell، نويسنده , , Allan Wissner، نويسنده , , Larry R. Feldberg، نويسنده , , Steven C. Kim، نويسنده , , Robert Mallon، نويسنده , , Eleonora D. Kovacs، نويسنده , , Lourdes Toral-Barza، نويسنده , , Constance A. Kohler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1407
To page
1410
Abstract
A series of 4-anilino-3-cyano-6,7-dialkoxyquinolines with different substituents attached to the 4-anilino group has been prepared that are potent MEK (MAP kinase kinase) inhibitors. The best activity is obtained when a phenyl or a thienyl group is attached to the para-position of the aniline through a hydrophobic linker, such as an oxygen, a sulfur, or a methylene group. The most active compounds show low nanomolar IC50ʹs against MEK (MAP kinase kinase), and have potent growth inhibitory activity in LoVo cells (human colon tumor line).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791420
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