Title of article
Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase
Author/Authors
Michael Taktakishvili، نويسنده , , Nouri Neamati، نويسنده , , Yves Pommier، نويسنده , , Vasu Nair، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
1433
To page
1435
Abstract
Integration of HIV viral DNA into human chromosomal DNA catalyzed by HIV integrase is essential for the replication of HIV. Discovery of novel inhibitors of HIV integrase is of considerable significance in approaches to the development of therapeutic agents against AIDS. We have synthesized a new dinucleotide 1 with an internucleotide phosphate bond that is unusually resistant to exonucleases. This compound exhibits potent anti-HIV-1 integrase activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791426
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