Title of article
Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues
Author/Authors
Laurent Schio، نويسنده , , Fabienne Chatreaux، نويسنده , , Véronique Loyau، نويسنده , , Michel Murer، نويسنده , , Anne Ferreira، نويسنده , , Pascale Mauvais، نويسنده , , Alain Bonnefoy، نويسنده , , Michel Klich، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1461
To page
1464
Abstract
A novel series of novobiocin analogues has been synthesised by removing the lipophilic aryl chain in novobiocin and introducing an amino substituent. The structural modifications have been dictated by the control of lipophilicity and the dissociation constant of the resulting compounds. Antibacterial activity of the new coumarin derivatives could be correlated with the amount of uncharged form in physiological conditions.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791432
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