Regio-reactive resin: A platform for orthogonal loading using the polymer backbone and cross-linker

A new support for solid-phase combinatorial organic synthesis has been developed, which we term a regio-reactive resin (R3-resin). The resin is based on a unique hydroxyl-functionalized cross-linker readily synthesized in two steps starting from 4-hydroxybenzaldehyde. The cross-linkerʹs ease of synthesis and high purity enables the preparation of gel-type resins with regio-reactive orthogonal loading sites. The resinʹs swelling properties were investigated, and its potential utility was demonstrated via orthogonal reactivity of the pendant and cross-linker sites.