Author/Authors :
Michele A. Weidner-Wells، نويسنده , , Kwasi A. Ohemeng، نويسنده , , Van N. Nguyen، نويسنده , , Stephanie Fraga-Spano، نويسنده , , Mark J. Macielag، نويسنده , , Harvey M. Werblood، نويسنده , , Barbara D. Foleno، نويسنده , , Glenda C. Webb، نويسنده , , John F. Barrett، نويسنده , , Dennis J. Hlasta، نويسنده ,
Abstract :
Amidino benzimidazoles have been identified as inhibitors of the bacterial KinA/Spo0F two-component system (TCS). Many of these inhibitors exhibit good in vitro antibacterial activity against a variety of susceptible and resistant Gram-positive organisms. The moiety at the 2-position of the benzimidazole was extensively modified. In addition, the regioisomeric benzoxazoles, heterocyclic replacements for the benzimidazole, have been synthesized and their activity against the TCS evaluated.
