Title of article
N-Me-pAB-Glu-γ-Glu-γ-Tyr(3-NO2): an internally quenched fluorogenic γ-glutamyl hydrolase substrate
Author/Authors
Jessica J. Pankuch، نويسنده , , James K. Coward، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1561
To page
1564
Abstract
A γ-glutamyl tripeptide containing an internally quenched fluorophore has been synthesized and shown to be a substrate for recombinant rat γ-glutamyl hydrolase. HPLC, LC–MS, and fluorescence spectra support the conclusion that selective hydrolysis occurs at the penultimate peptide bond. Preliminary data indicate that hydrolysis of this substrate can be monitored continuously to yield steady-state kinetic data
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791453
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