Title of article
Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I
Author/Authors
Todd J. Zahn، نويسنده , , Jessica Whitney، نويسنده , , Carolyn Weinbaum، نويسنده , , Richard A. Gibbs، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1605
To page
1608
Abstract
A stereocontrolled synthetic route has been used to prepare two of the geometric isomers of all-trans-GGPP. Neither of these isomers is effective substrates for mammalian GGTase I, but 3 is a potent inhibitor of this enzyme (IC50=100 nM). Surprisingly, both compounds are effective substrates for mammalian FTase.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791462
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