Author/Authors :
Mark A. Massa، نويسنده , , Dale P. Spangler، نويسنده , , Richard C. Durley، نويسنده , , Brian S. Hickory، نويسنده , , Daniel T. Connolly، نويسنده , , Bryan J. Witherbee، نويسنده , , Mark E. Smith، نويسنده , , James A. Sikorski، نويسنده ,
Abstract :
A series of novel N,N-disubstituted trifluoro-3-amino-2-propanols has been prepared as potent inhibitors of cholesteryl ester transfer protein (CETP). Modifying the aromatic 3-tetrafluoroethoxy group in the lead molecule 1a with various heteroaryl moieties produced new 2-furyl analogues 2a,b with submicromolar potency in vitro.
