Author/Authors :
Stephen L. Gwaltney II، نويسنده , , Hovis M. Imade، نويسنده , , Qun Li ، نويسنده , , Laura Gehrke، نويسنده , , R. Bruce Credo، نويسنده , , Robert B. Warner، نويسنده , , Jang Yun Lee، نويسنده , , Peter Kovar، نويسنده , , David Frost، نويسنده , , Shi-Chung Ng، نويسنده , , Hing L. Sham، نويسنده ,
Abstract :
The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
