Author/Authors :
Tetsuji Kawamoto، نويسنده , , Yoshihiro Ikeuchi، نويسنده , , Yuji Mikata، نويسنده , , Maki Kishigami، نويسنده , , Shigenobu Yano، نويسنده , , Chieko Murayama، نويسنده , , Tomoyuki Mori، نويسنده , , Fumio Yoneda، نويسنده ,
Abstract :
6-Nitro- and 8-nitro-5-deazaflavin derivatives have been found to enhance prominently the radiation-induced formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) at the expense of formation of 2,6-diamino-4-hydroxy-5-formamidopyrimidine nucleosides (FapydGuo) both in deaerated and in N2O saturated aqueous 2′-deoxyguanosine solutions. The radiosensitizing capacity of a 9-nitro-5-deazflavin derivative was observed only in the N2O saturated aqueous solutions.
