Author/Authors :
Thierry Beltran، نويسنده , , David Egron، نويسنده , , Alain Pompon، نويسنده , , Isabelle Lefebvre، نويسنده , , Christian Perigaud، نويسنده , , Gilles Gosselin، نويسنده , , Anne-Marie Aubertin، نويسنده , , Jean-Louis Imbach، نويسنده ,
Abstract :
A new pronucleotide series is described involving a two-step degradation process mediated by, respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK− cell line, which proves 5′-AZTMP delivery.
