Author/Authors :
Charles Q. Meng، نويسنده , , X. Sharon Zheng، نويسنده , , Lisa A. Holt، نويسنده , , Lee K. Hoong، نويسنده , , Patricia K. Somers، نويسنده , , Russell R. Hill، نويسنده , , Uday Saxena، نويسنده ,
Abstract :
A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimmune and allergic inflammatory diseases. Structure–activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression.
