Title of article
Nicotinamide N-Oxides as CXCR2 antagonists
Author/Authors
Neil S. Cutshall، نويسنده , , Rocky Ursino، نويسنده , , Kristin A. Kucera، نويسنده , , John Latham، نويسنده , , Nathan C. Ihle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1951
To page
1954
Abstract
A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-α-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791540
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