Title of article
αvβ3 Antagonists Based on a Central Thiophene Scaffold
Author/Authors
Anusch Peyman، نويسنده , , Karl-Heinz Scheunemann، نويسنده , , David W. Will، نويسنده , , Jochen Knolle، نويسنده , , Volkmar Wehner، نويسنده , , Gerhard Breipohl، نويسنده , , Hans Ulrich Stilz، نويسنده , , Denis Carniato، نويسنده , , Jean-Marie Ruxer، نويسنده , , Jean-Francois Gourvest، نويسنده , , Marielle Auberval، نويسنده , , Bernard Doucet، نويسنده , , Roland Baron، نويسنده , , Martine Gaillard، نويسنده , , Thomas R. Gadek، نويسنده , , Sarah Bodary، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2011
To page
2015
Abstract
A series of novel, highly potent αvβ3 antagonists based on a thiophene scaffold and containing an acylguanidine as an Arg-mimetic is described. A number of structural features, such as cyclic versus open guanidine and a variety of lipophilic side chains, carbamates, sulfonamides and β-amino acids were explored with respect to inhibition of αvβ3 mediated cell adhesion and selectivity versus αIIbβ3 binding. In addition, compound 19 was found to be active in the TPTX model of osteoporosis.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791554
Link To Document