Title of article
Design and Synthesis of a Highly Selective EP2-Receptor Agonist
Author/Authors
Kousuke Tani، نويسنده , , Atsushi Naganawa، نويسنده , , Akiharu Ishida، نويسنده , , Hiromu Egashira، نويسنده , , Kenji Sagawa، نويسنده , , Hiroyuki Harada، نويسنده , , Mikio Ogawa، نويسنده , , Takayuki Maruyama، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Kigen Kondo، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2025
To page
2028
Abstract
EP2-receptor selective agonist 3 was identified by the structural hybridization of butaprost 1a and PGE22a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE22a stimulated uterine motility.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791557
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