Author/Authors :
Kousuke Tani، نويسنده , , Atsushi Naganawa، نويسنده , , Akiharu Ishida، نويسنده , , Hiromu Egashira، نويسنده , , Kenji Sagawa، نويسنده , , Hiroyuki Harada، نويسنده , , Mikio Ogawa، نويسنده , , Takayuki Maruyama، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Kigen Kondo، نويسنده , , Masaaki Toda، نويسنده ,
Abstract :
EP2-receptor selective agonist 3 was identified by the structural hybridization of butaprost 1a and PGE22a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE22a stimulated uterine motility.
