Title of article
Design and synthesis of a highly selective EP4-receptor agonist. part 1: 3,7-dithiaPG derivatives with high selectivity
Author/Authors
Toru Maruyama، نويسنده , , Masaki Asada، نويسنده , , Tai Shiraishi، نويسنده , , Akiharu Ishida، نويسنده , , Hiromu Egashira، نويسنده , , Hideyuki Yoshida، نويسنده , , Takayuki Maruyama، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Kigen Kondo، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2029
To page
2031
Abstract
A series of 3,7-dithiaPGE1 analogues 3, 4, 11, 16 and 19 were identified as highly selective EP4-receptor agonists starting from the chemical modification of 7-thiaPGE1 analogue 1. EP4-receptor selectivity and agonist activity were maximized in 3 and 4.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791558
Link To Document