Title of article
Synthesis and Photodynamic Action of Diphenyl-2,3-dihydroxychlorin: a Potential Tumor Photosensitizer
Author/Authors
Tian Yu Wang، نويسنده , , Hui Long Liu، نويسنده , , Jing Rong Chen، نويسنده , , Fan Guang Liu، نويسنده , , Ying Gu، نويسنده , , Jin Shi Ma، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2049
To page
2052
Abstract
The synthesis, photophysical properties of diphenyl-2,3-dihydroxychlorin (DPCOH) and its photocytotoxicity to tumor cells are described. DPCOH exhibits photodynamic activity in terms of type I and type II mechanisms under irradiation. The quantum yield of 1O2 in CHCl3 is 0.7. For the photocytotoxicity to tumor cells, DPCOH proved to be 200 times more potent than HPD, and the dark toxicity is low (dark IC90>32 μg/mL).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791563
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