Title of article
Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems
Author/Authors
Yuji Kasuya، نويسنده , , Zheng-Rong Lu، نويسنده , , Pavla Kope kov?، نويسنده , , Jind ich Kope ek، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2089
To page
2091
Abstract
The 17-methoxy group of geldanamycin was substituted with 1,3-diaminopropane and 1,3-diamino-2-hydroxypropane to introduce a primary amino group useful for conjugation with targeting moieties and drug carriers. We have developed a procedure that has provided improved yield and reproducibility of the syntheses. Both geldanamycin derivatives demonstrated antiproliferative activity towards the human ovarian carcinoma cell line, A2780.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791573
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