Title of article
Stereoselective synthesis and antibacterial evaluation of 4-amido-isothiazolidinone oxides
Author/Authors
Zhuoliang Chen، نويسنده , , Thomas P. Demuth Jr.، نويسنده , , Fred C. Wireko، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2111
To page
2115
Abstract
Two well-defined oxidative chlorination–cyclization processes have been developed for the stereoselective synthesis of a variety of 4-amido-isothiazolidinone oxide derivatives. The stereochemistry of the cyclization products was confirmed by X-ray crystallography. These new compounds were designed as bacterial serine protease inhibitors. In tests, some of them showed weak antibacterial activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791578
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