Title of article
Novel Lipase-Catalysed Enantioselective Deacetylation of (±)-5-Acetoxy-3-(4-fluorophenyl)-2-phenylisoxazolidine
Author/Authors
Shubhasish Mukherjee، نويسنده , , Ashok K. Prasad، نويسنده , , Virinder S. Parmar، نويسنده , , Oliver W. Howarth، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2117
To page
2121
Abstract
(±)-5-Acetoxy-3-(4-fluorophenyl)-2-phenylisoxazolidine has been synthesised by a highly diastereoselective [3+2] cycloaddition reaction between α-(4-fluorophenyl)-N-phenylnitrone and vinyl acetate in good yield. Candida rugosa lipase catalyses the deacetylation of this (±)-5-acetoxyisoxazolidine in a highly enantioselective fashion in diisopropyl ether containing n-butanol affording (−)-5-acetoxy-3-(4-fluorophenyl)-2-phenylisoxazolidine in 43% yield and >99% ee.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791579
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