Title of article
Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III
Author/Authors
Amjad Ali، نويسنده , , Susan D. Aster، نويسنده , , Donald W. Graham، نويسنده , , Gool F. Patel، نويسنده , , Gayle E. Taylor، نويسنده , , Richard L. Tolman، نويسنده , , Ronald E. Painter، نويسنده , , Lynn L. Silver، نويسنده , , Katherine YOUNG، نويسنده , , Kenneth Ellsworth، نويسنده , , Wayne Geissler، نويسنده , , Georgianna S. Harris، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2185
To page
2188
Abstract
4-Substituted 2-amino-6-(anilino)pyrimidines have been found to be selective inhibitors of DNA polymerase III, a replicative enzyme known to be essential in the DNA synthesis of Gram-positive bacteria. Among the analogues, 18 displayed an IC50 of 10 μM against DNA polymerase III from Staphylococcus aureus.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791594
Link To Document