Author/Authors :
Thais M. Sielecki، نويسنده , , Jie Liu، نويسنده , , Shaker A. Mousa، نويسنده , , Adrienne L. Racanelli، نويسنده , , Elizabeth A. Hausner، نويسنده , , Ruth R. Wexler، نويسنده , , Richard E. Olson، نويسنده ,
Abstract :
Selective antagonism of the platelet GPIIb/IIIa receptor represents an attractive mechanism for the prevention and treatment of a number of thrombotic disease states. The antiplatelet activity of the oral GPIIb/IIIa receptor antagonists DMP 754 and DMP 802 have been disclosed. In this paper, the synthesis and biological evaluation of a series of potent N-substituted benzamidine isoxazolines are explored. The effect of benzamidine substitution on the duration of antiplatelet efficacy in dog is presented.
