Author/Authors :
Jeffrey M. Dener، نويسنده , , Vivian R. Wang، نويسنده , , Kenneth D. Rice، نويسنده , , Anthony R. Gangloff، نويسنده , , Elaine Y. -L. Kuo، نويسنده , , William S. Newcomb، نويسنده , , Daun Putnam، نويسنده , , Martin Wong، نويسنده ,
Abstract :
Truncation of potent and selective dibasic inhibitors afforded monocharged inhibitors of human mast-cell tryptase. Using two classes of analogues as lead structures, several monocharged derivatives were identified with Ki values ranging from 0.084 to 0.21 μM against the enzyme.
