Author/Authors :
Rolf W. Feenstra، نويسنده , , Janpeter de Moes، نويسنده , , Jos J. Hofma، نويسنده , , Henk Kling، نويسنده , , Wilma Kuipers، نويسنده , , Stephen K. Long، نويسنده , , Martin Th. M. Tulp، نويسنده , , Jan A. M. van der Heyden، نويسنده , , Chris G. Kruse، نويسنده ,
Abstract :
This paper describes the syntheses of several 1-aryl-4-(biarylmethylene)piperazines and the results of the determination of their affinity for D2 and 5-HT1A receptors. A selection of these compounds was evaluated in vivo, resulting in the identification of a drug candidate which is being clinically evaluated as a potential atypical antipsychotic with reduced extrapyrimidal side effects.
