Title of article
New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-receptor and serotonin 5-HT1A-receptor affinities
Author/Authors
Rolf W. Feenstra، نويسنده , , Janpeter de Moes، نويسنده , , Jos J. Hofma، نويسنده , , Henk Kling، نويسنده , , Wilma Kuipers، نويسنده , , Stephen K. Long، نويسنده , , Martin Th. M. Tulp، نويسنده , , Jan A. M. van der Heyden، نويسنده , , Chris G. Kruse، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2345
To page
2349
Abstract
This paper describes the syntheses of several 1-aryl-4-(biarylmethylene)piperazines and the results of the determination of their affinity for D2 and 5-HT1A receptors. A selection of these compounds was evaluated in vivo, resulting in the identification of a drug candidate which is being clinically evaluated as a potential atypical antipsychotic with reduced extrapyrimidal side effects.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791629
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