Title of article :
Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are selective α-Mannosidase inhibitors
Author/Authors :
Florence Popowycz، نويسنده , , Sandrine Gerber-Lemaire، نويسنده , , Raynald Demange، نويسنده , , Eliazar Rodriguez-Garc?a، نويسنده , , Ana Teresa Carmona Asenjo، نويسنده , , Inmaculada Robina، نويسنده , , Jean-Claude Hausmann and Pierre Vogel، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (Ki=7.4 μM) and selective inhibition of α-mannosidase from jack bean has been found for (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol and other derivatives.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
